ISSN 1995-5537
«Biotechnology» journal, Vol. 3, No. 2, 2010
Р. 56-61, Bibliography. 8, Ukrainian..
Universal Decimal classification: 577.3:615.28:547.495.9
Universal Decimal classification: 577.3:615.28:547.495.9
Epizootology Institute of Ukrainian Academy of the Agrarian Sciences, Rivne
Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine
Results influence of different polyhexamethyleneguanidine hydrochloride concentrations influence on ion conductivity through a double layer phospholipid membrane used as a model of microorganism native membrane are given. The polyhexamethyleneguanidine hydrochloride effect on a bilayer membrane was specific with a threshold esteblished to be 0.2 mg/l. The nondamaging polyhexamethyleneguanidine hydrochloride concentration that protects from contracting horse retinopneumoniae herpesvirus has also been found for monolayer fibroblast culture of chicken embryo. The results obtained prove irreversible character of polyhexamethyleneguanidine hydrochloride binding to a lipid bilayer and fibroblast cells plasma membranes.
Key words: polyhexamethyleneguanidine hydrochloride, phospholipid membrane, fibroblasts, herpesvirus.
© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2008