ISSN 2410-7751 (Print)
ISSN 2410-776X (Online)
Biotechnologia Acta V. 18, No. 6, 2025
P. , Bibliography , Engl.
UDC: 004.9:612.822
doi:
Full text: (PDF, in English)
HYPOXIC EFFECTS IN EXTREME STRESSFUL CONDITIONS: SOME RESEARCH TECHNOLOGIES FOR IMPROVING HEALTH AND LONGEVITY
O.M. KLYUCHKO 1, Yu.M. ONOPCHUK 2, G.V. LIZUNOV 3, K. S. LYMAN 4, A. G. LIZUNOVA 5
1 State University "Kyiv Aviation Institute"
2 Institute of Cybernetics of V. M. Glushkov National Academy of Sciences, Kyiv, Ukraine
3 Space Research Institute of the National Academy of Sciences of Ukraine, Kyiv
4 Washington State University, USA
5 Luxoft Global Operations GmbH: Zug, CH, USA
Aim. Description of some technologies of many years of research and their results in the age aspect in extreme situations (such as hypoxia), application of these technologies to improve the survival of organisms in stressful situations, their treatment and rehabilitation, as well as longevity.
Methods. Numerous observations on changes in biometric indicators in the comparative-age aspect of individuals in extreme highland conditions using standard methods of laboratory analysis of bioindicators in mountain conditions were analyzed. The digital indicators input to databases; mathematical, program modeling were used.
Results. The data on observations and measurements of various physiological characteristics of people, presented in a comparative age aspect, are presented. The influence of high-altitude factors on the longevity of bioorganisms, as well as some problems in aging physiology and hypoxic states, is described. The results of examinations of veteran climbers regarding adaptation to hypoxic barium, active gradual (stepwise) adaptation, the hypoxic therapy method, and combinations of these methods are discussed. A mathematical model of ischemic heart disease is presented, and technologies for the survival of people of different ages under extreme, stressful conditions are developed.
Conclusion. Hypoxybaria increases an organism's resistance, protects against premature aging,
and promotes longevity. With age, an organism's ability to adapt to hypoxia decreases, but is not
entirely lost (older people can adapt up to 5000 m a.s.l.) The obtained results are essential for the
further development of technologies for the survival of human of different ages in extreme, stressful
conditions, their treatment, and rehabilitation.
Keywords: hypoxia, adaptation, extreme stressful conditions, numerical indices of physiological functions, long-livers, mathematical modeling
© Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, 2025