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ISSN 2410-7751 (Print)
ISSN 2410-776X (Online)


Biotechnologia Acta V. 13, No 3, 2020
Р. 81-88, Bibliography 15, English
Universal Decimal Classification: 628.3


L. Sabliy, V. Zhukova

National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”

The work was aimed to study the processes of industrial wastewater purification of a pharmaceutical company treatment and to recommend an effective technology for local treatment of such wastewater in accordance with the requirements of normative documents on the treated wastewater disposal into the urban sewerage system.

Model solutions of cefuroxime, a cephalosporin antibiotic, in distilled water with a concentration of 25 and 35 mg/dm3 were used for the study. COD model solutions, which is, respectively, 90 and 120 mg/dm3. Chemical  oxygen demand was  etermined by the dichromate  method (according to the guiding normative document (GND) “Methods for Chemical Oxygen Demand (COD) Determining in Surface and Wastewater”).

The proposed technology included the following successive processes of physical and chemical treatment of wastewater: aeration – equalization of quantitative and qualitative composition of wastewater and oxidation up to 30% of organic matter; coagulation – removing of antibiotics from wastewater by their adsorption on a highly developed surface of mineral coagulants flakes; sedimentation – separating of the formed flakes; oxidation of antibiotics destruction products by hydrogen peroxide; filtration – removal of fine impurities.Effect of COD reduction rate in the coagulation and setteling of wastewater in the case of ferrous sulphate III was 79.2% and 75%, which is higher by 4.2-6.7% than when using aluminum sulphate. The  COD  index  changing  of  the  pharmaceutical  enterprise  wastewater  by  the  stages  of  its purification was found as follows: “aeration — coagulation with iron sulfate III — sedimentation — oxidation — filtration”. After filtering effect of reducing COD index was 95.8-100% at the initial value of 120 and 90 mg/dm3 respectively. The technology of local wastewater treatment from antibiotics was developed, which was based on the consistent use of physico-chemical methods of treatment and enabled to remove antibiotics and related substances from wastewater in accordance with the requirements of normative documents and disposal of treated wastewater into the urban wastewater system.

Application of the developed technology of local wastewater treatment from antibiotics and related substances  by  the  pharmaceutical  companies  would  lead  to  meet  the  requirements  of  industrial wastewater  disposal  into  the  city  drainage  system,  to  a  significant  risk  reduction  of  the  antibiotics influence  on  the  microorganisms  of  active  sludge  of  the  urban  wastewater  biological  treatment facilities, to operating costs reduction to achieve maximum allowable discharges (MAD) of wastewater into a natural reservoir.

Key words: antibiotics, wastewater, treatment, pharmaceutical enterprises.

© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2020