ISSN 2410-7751 (Print)
ISSN 2410-776X (on-line)
"Biotechnologia Acta" V. 9, No 3, 2016
https://doi.org/10.15407/biotech9.03.023
Р. 23-36, Bibliography 76, English
Universal Decimal Classification: 577.1:547.979.4:60-022.532
PROSPECTS OF CURCUMIN USE IN NANOBIOTECHNOLOGY
Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, Kyiv
The aim of the work was a generalization of literature data on the prospects for curcumin usage in biotechnology as a component for biologically active nanocomplexes with anti-inflammatory and antioxidant activity creation. It is emphasized that their effectiveness depends on the solubility in aqueous medium and on the metabolism rate decreasing in the body. Current trend is the development of creation methods of hydrophilic curcumin-based nanostructures to increase the time of its biological action. Its nanostructures with silicium, polylysine, copolymers of lactic and glycolic acids and metal ions are the most promising in this respect. For multicomponent hybrid nanoparticles effective usage the substantiation of their component combined use features is necessary. The practical task is to create and to study the functional properties of such combined nanocomplexes. Curcumin complex with metal ions creation contributes to its water solubility and to increase the efficiency of biological action. These complexes have specific characteristics depending on the nature of metal ion. The creation of curcumin-based biocompatible nanocomposites with amplifiers of its action that are known pharmaceuticals is perspective. Such multifunctional nanocomplexes will facilitate the targeted medicines delivery to the places of pathological processes localization and the reduction of their side effects.
Key words: curcumin, multicomponent nanocomplexes.
© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2016
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