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ISSN 1995-5537

2 2009

"Biotechnology" journal Vol. 2, No. 2, 2009
Р. 86-97, Bibliography 13, Ukraininan.
Universal Decimal classification: 546.28+577.115/.15+581.4+615.9:001.5

State Institution «Institute for Occupational Health of AMS of Ukraine», Kyiv

The comparative study on the effect of powders of amorphous highly dispersed SiO2 nanoparticles (6–7 nm and 54–55 nm) and powder of standard large-disperse Lyuberets quartz PQ-3 after single intratracheal administration in the dose of 50 mg in 3-month experiment was carried out. During the experiment it was observed: eosinophilic reaction in peripheric blood; preferred formation of cell hypersensitivity reaction of emmediate action; disorders in prooxidant-antioxidant balance in lungs, liver, erythrocytes and blood plasma; inhibition of lipid peroxidation in blood plasma and in lung and activation in liver; changes of antioxidant defence and cholinesterase activity. Damaging effects rising of the nanoparticles powders on the rats organisme by the end of the experiment was established. There was concluded that inhalanion of amorphous highly disperse SiO2 nanoparticles into a worker’s organism in working conditions is dangerous for health.

Key words: SiO2 nanoparticles, large disperse Lyuberets quartz PQ-3, intratracheal administration, blood leucocytes, lipid peroxidation, antioxidant defence.

© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2008