ISSN 1995-5537

"Biotechnology" journal Vol. 2, No. 2, 2009
Р. 86-97, Bibliography 13, Ukraininan.
Universal Decimal classification: 546.28+577.115/.15+581.4+615.9:001.5

The comparative study on the effect of powders of amorphous highly dispersed SiO₂ nanoparticles (6–7 nm and 54–55 nm) and powder of standard large-disperse Lyuberets quartz PQ-3 after single intratracheal administration in the dose of 50 mg in 3-month experiment was carried out. During the experiment it was observed: eosinophilic reaction in peripheric blood; preferred formation of cell hypersensitivity reaction of emmediate action; disorders in prooxidant-antioxidant balance in lungs, liver, erythrocytes and blood plasma; inhibition of lipid peroxidation in blood plasma and in lung and activation in liver; changes of antioxidant defence and cholinesterase activity. Damaging effects rising of the nanoparticles powders on the rats organisme by the end of the experiment was established. There was concluded that inhalanion of amorphous highly disperse SiO₂ nanoparticles into a worker’s organism in working conditions is dangerous for health.

Key words: SiO₂ nanoparticles, large disperse Lyuberets quartz PQ-3, intratracheal administration, blood leucocytes, lipid peroxidation, antioxidant defence.