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ISSN 1995-5537

1 2009

"Biotechnology" journal Vol. 2, No. 1, 2009
Р. 80- 87, Bibliography 16, Russian.
Universal Decimal classification: 546.28+577.115/.15+581.4+615.9:001.5

State Institution «Institute for Occupational Health of AMS of Ukraine», Kyiv
The comparative study on the effect of powders of amorphous highly disperse SiO2 nanoparticles (6–7 nm and 54–55 nm) and the powder of the standard Lyuberets quartz PQ-3 after single intratracheal administration in the dose of 50 mg in 3-month experiment was conducted. Under the experiment following changes were observed: transitory decrease of the relative mass of adrenal glands as a sign of the stress effect; persistent hyperemia in inner organs (lungs, liver, kidneys, myocardium), infiltration of their stroma by histiocytes, leucocytes, lymphocytes and plasma cells and the focus of large granular protein dystrophy. The powders of nanoparticles caused more expressed damage in bronchi mucose and morphological disorders in kydney than the powder of the standard Lyuberets quartz PQ-3. There was concluded, that inhalanion of amorphous highly disperse SiO2 nanoparticles into worker’s organism in production conditions is dangerous to health.

Key words: nanoparticles of SiO2, Lyuberets quartz PQ-3, intratracheal administration, inner organs morphology.

© Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, 2008