BLOOD METALLOPROTEINS IN RATS UNDER CONDITIONS OF ENERGY DRINK CONSUMPTION KH.Y. PARTSEI, M.B. ARTYSH, Н.M. ERSTENIUK, H.V. TOKARYK, T.P. Maksymchuk

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ISSN 2410-7751 (Print)
ISSN 2410-776X (Online)

cover biotech acta general

Biotechnologia Acta Т. 18, No. 2, 2025
P. , Bibliography 6 , Engl.

UDC 577.112+616.15+616-092.9+663.85
BLOOD METALLOPROTEINS IN RATS UNDER CONDITIONS OF ENERGY DRINK CONSUMPTION
KH.Y. PARTSEI, M.B. ARTYSH, Н.M. ERSTENIUK, H.V. TOKARYK,
T.P. Maksymchuk
Ivano-Frankivsk National Medical University,
Ivano-Frankivsk
Abstract. The study aimed to evaluate the effect of energy drinks on the level of Cu, Fe, ceruloplasmin, and transferrin activity in the blood of rats.
Materials and methods. The study was conducted on white male Wistar rats divided into two groups: control and experimental. The experimental group received the energy drink Burn for 30 days. Blood samples were taken under anesthesia by decapitation on the 1st day after the drink was discontinued. The content of Cu and Fe was determined by atomic absorption spectrophotometry. Ceruloplasmin activity and transferrin saturation were studied by the method of Babenko G.O.
Results. Against the background of energy drink consumption in the experimental group, a decrease in the level of Cu by 43% and Fe by 67% was observed compared to the control. Transferrin saturation decreased by 42% and ceruloplasmin activity by 40%. The data obtained indicate that the consumption of an energy drink causes complex changes in the metabolism of Cu and Fe, which is reflected in a decrease in the level of these trace elements in the blood and the activity of metalloenzymes, in particular ceruloplasmin and transferrin, which can lead to the development of oxidative stress and impaired functioning of both individual organs and the body as a whole.
Conclusions. The results obtained indicate the development of dysmicroelementosis in the context of energy drink consumption, which can have adverse effects on the functioning of red blood cells, body systems, and tissues, an increase in the level of endogenous intoxication, and impaired tissue respiration.
Keywords: energy drink, rats, blood, Cu, Fe, сeruloplasmin, transferrin saturation.