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ISSN 2410-7751 (Print)
ISSN 2410-776X (Online)

 6 2014

"Biotechnologia Acta" v. 7, no 6, 2014
Р. 102-108, Bibliography 56, English
Universal Decimal classification: 576.314.63.004.15:005]:617-089.844


A. V. Oberemko, A. G. Popandopulo

Government Institution «Institute of Urgent and Recovery Surgery named after Gusak of
Ukrainian National Academy of Medical Sciences», Donetsk

This review presents a generalized definition of vesicles as bilayer extracellular organelles of all celular forms of life:  not only eu-, but also prokaryotic. The structure and composition of extracellular vesicles, history of research, nomenclature, their impact on life processes in health and disease are discussed. Moreover, vesicles may be useful as clinical instruments for biomarkers, and they are promising as biotechnological drug.  However,  many  questions  in  this  area  are  still  unresolved  and  need  to  be addressed in the future.

The most interesting from the point of view of practical health care represents a direction to study the effect of exosomes and microvesicles in the development and progression of a particular disease, the possibility of adjusting the pathological process by means of extracellular vesicles of a particular type, acting as an active ingredient. Relevant is the further elucidation of the role and importance of exosomes to the surrounding  cells,  tissues  and  organs  at  the  molecular  level,  the  prospects  for  the  use  of  non-cellular vesicles as biomarkers of disease.

Key words: exosomes, microvesicles.

© Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, 2014