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ISSN 1995-55

«Біотехнологія» journal V. 5, No. 4, 2012
Р. 112-118, Bibliography 18, Russian.
Universal Decimal classification: 611.018.26:576.54


Yu. О. Petrenko, N. O. Volkova, V. F. Kutsevliak, V. I. Kutsevliak, O. Yu. Petrenko

Institute for Problems of Cryobiology and Cryomedicine of National Academy of Sciences of Ukraine, Kharkiv;

Kharkiv State Medical University;

Kharkiv Medical Academy of Postgraduate Education;

State Enterprise «Interdepartmental Research Center of Cryobiology and Cryomedicine,
of National Academy of Sciences of Ukraine,

National Academy of Medical Sciences of Ukraine, Ministry of Health of Ukraine»

The development of hybrid bone tissue bioequivalents with the application of tissue engineering approaches is one of the promising trends of current biotechnology. Biocompatibility of osteoplastic composite materials, which were approved for clinical application with adipose tissue mesenchymal stromal cells (AT MSC) in vitro was studied. It is shown that the presence of «Colapol» sponges, as well as OssaBase®-НА and Bio-Oss® granules did not affect the viability and metabolic activity of cells, whereas «Stimul-Oss» had toxic effect. After seeding into «Colapol» sponges, as well as OssaBase®-НА and Bio-Oss®, granules AT MSC adhered to the scaffold surfaces, confirming the application potential of these materials for the development of AT MSC based bioengineered constructs for the reconstruction of bone defects in facial-cranial surgery and dentistry.

Key words: adipose tissue mesenchymal stromal cells, osteoplastic materials, biocompatibility, tissue engineering.

© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2008