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ISSN 1995-5537

1 2008

“Biotechnology” journal Vol. 1, No. 1, 2008
P. 40-45, Bibliography. 38, English
Universal Decimal classification: 612.173:576.343


L. L. Lukash

Institute of Molecular Biology and Genetics of National Academy of Sciences of Ukraine, Kyiv

 The review article is devoted to cellular cardiomyoplasty as a novel technology of treatment of cardiac insufficiency. The experiments on animals and the first clinical trials have shown the possibility to improve the contractile function of diseased heart after transplantation of different types of donor cells: cardiomyocytes, bone marrow enriched by hematopoietic stem cells and mesenchymal stem cells. The problems of cellular cardiomyoplasty are discussed.

Key words: Cellular cardiomyoplasty, stem cell, cardiomyocyte, differentiation, tissue engineering in vitro, experimental models of myocardial infarction in vivo, autologeous, allogenic and xenogenic transplantation.

© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2008