USE OF NANODIAMONDS IN BIOMEDICINE M. I. Kanyuk

Details: Hits: 2335

ISSN 2410-7751 (Print)
ISSN 2410-776X (Online)

2 2015

Biotechnologia Acta" V. 8, No 2, 2015
https://doi.org/10.15407/biotech8.02.009

Р. 9-25, Bibliography 78, English
Universal Decimal classification: 577.1; 60-022.513.2

Palladin Biochemistry Institute of the National Academy of Sciences of Ukraine, Kyiv

The aim of this work is to summarize the literature data concerning the strategy of creating of methods of efficient nanotherapy and targeted drug delivery. It was shown that the developed methods of post-refining, control surface cleanliness and creating different types of hydrophilic surface of nanodiamonds provide ample opportunities for high-quality surface functionalization of organic compounds.

Modern direction of nanomedicine is creation of complex biocompatible nanomaterials with antitumor activity that promote the targeted drug transport in the place of localization of pathological process. To provide targeted drug delivery C₆₀-fullerens, nanoporous silica, carbon nanotubes and nanodiamonds are widely used. The combination of nanodiamonds with other nanoparticles and their association with drugs can be considered as a promising strategy to overcome tumor resistance to the drug action. It can be suggested that nanodiamonds coated with polyethylene glycol is the way to create the stable and selective carriers of new types. They have to be biocompatible, stable, possess higher dispersion in biological media and avoid recognition by the immune system. Such composites effectively enter the cell cytoplasm via clathrin –mediated endocytosis. Hybrid nanocarriers will become the basis for the targeted and controlled release of high concentrations of antineoplastic chemoterapeutic agents within the cytosol of the cancer cells with minimal non-specific binding and toxicity towards normal cells.

Key words: nanodiamonds, hybrid nanocarriers, biomedicine.

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