ISSN 1995-5537
"Biotechnology" journal Vol. 3, No. 4, 2010
Р. 62-66, Bibliography 23, English.
Universal Decimal classification: 547.9
GENERATION OF REACTIVE OXYGEN SPECIES BY MULTI-WALLED CARBON NANOTUBES UNDER LIGHT IRRADIATION
Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of National Academy of Sciences of Ukraine, Kyiv;
Lashkaryov Institute of Semiconductor Physics of National Academy of Sciences of Ukraine, Kyiv;
Kyiv National Taras Shevchenko University, Kyiv;
Institute of Physics, Chemical Laboratory, Technical University of Ilmenau, Germany
Reactive oxygen species (ROS) were generated as a result of the photoexcitation of multi-walled carbon nanotubes (MWCNT) in water. ROS levels were detected using electron paramagnetic resonance spectroscopy and spin traps. Irradiation of MWCNT with visible and near infrared light in water was followed by the generation of superoxide radical anions. The effect of a self-induced ROS generation after photoirradiation of MWCNT has been investigated. Photoirradiated MWCNT may be useful for photodynamic therapy of tumors through ROS generation.
Key words: multi-walled carbon nanotubes, reactive oxygen species, light irradiation, electron paramagnetic resonance spectroscopy, photodynamic therapy of tumors.
© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2008