ISSN 1995-5537
"Biotechnology" journal Vol. 2, No. 1, 2009
Р. 24-34, Bibliography 43, Ukrainian.
Universal Decimal classification: 577.322.7: 577.112.386.2
DISULFIDE BONDS IN STRUCTURAL AND FUNCTIONAL PROTEIN ORGANIZATION
Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, Kyiv
Modern vision about disulfide bonds role in light of providing the structural and functional properties of blood plasma proteins is proposed. New approaches concerning recombinant and secretory proteins refolding are generalized. A problem concerning oxidative folding and disulfide bonds significance for secretory protein posttranslation ripening inside of endoplasmic reticulum with reductase enzyme system participation is discussed.
Key words: disulfide bonds, secretory proteins, plasminogen, oxidative folding, proteins renaturation.
© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2008