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ISSN 2410-776X (Online),
ISSN 2410-7751 (Print)

 3 2015

Biotechnologia Acta V. 8, No 3, 2015
https://doi.org/10.15407/biotech8.03.078
Р. 78-88, Bibliography 88, English
Universal Decimal Classification: 612.015:616.153.96:616.894

INFLUENCE OF CURCUMIN ON CYTOKINES CONTENT AND ANGIOTENSIN-CONVERTING ACTIVITY UNDER INTRAHIPPOCAMPUS ADMINISTRATION OF β-AMYLOID PEPTIDE IN RATS

Sokolik V. V.1, Shulga S. M.2

1State Institution “Institute of Neurology, Psychiatry and Narcology of the National Academy of Medical Sciences of Ukraine”, Kharkiv
2State Institution “Institute for Food Biotechnology and Genomics of the National Academy of Sciences of Ukraine”, Kyiv

The purpose of this study was to investigate the effect of curcumin on cytokine response and angiotensin-converting activity in terms of intrahippocampus administration of β-amyloid peptide in rats. Animals with experimental model of Alzheimer’s disease received nasal therapy aqueous solution of curcumin. Recorded concentration of cytokines (interleukin-1β, interleukin-6, interleukin-10, tumor necrosis factor-α) and angiotensin-converting activity in the parts of the brain (cerebral cortex and hippocampus) and blood serum, as well as indicators of conditional reflex escapers action. Install a reduction in cytokine response intrahippocampus administering Aβ42_Human and angiotensin-converting activity inhibition in the brain but not in the blood serum of animals under the action of curcumin. Recorded improvement in cognitive performance in rats with a model of Alzheimer’s disease as a result of curcumin therapy. Nasal treatment with an aqueous solution of curcumin has anti-inflammatory effect in the targeted parts of the brain (сerebral cortex and hippocampus), but inhibits angiotensin-converting activity.

Кey words: curcumin, β-amyloid peptide, cytokines, angiotensin-converting enzyme, Alzheimer’s disease.

© Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, 2015