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Home Archive 2015 № 1 NANOMATERIALS IN THE DIAGNOSIS AND THERAPY OF DIABETES MELLITUS M. V. Tolkachev, K. I. Bogutska, O. M. Savchuk, Yu. І. Prylutskyy
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ISSN 2410-7751 (Print)
ISSN 2410-776X (Online)

Biotechnologia Acta
V. 8, No 1, 2015


Biotechnologia Acta v. 8, No 1, 2015;
doi: 10.15407/biotech8.01.009
Р. 19-31, Bibliography 97, English
Universal Decimal classification: 541.64: 57.013: 612.349: 615.012

NANOMATERIALS IN THE DIAGNOSIS AND THERAPY OF DIABETES MELLITUS

M. V. Tolkachev, K. I. Bogutska, O. M. Savchuk, Yu. І. Prylutskyy

Taras Shevchenko National University of Kyiv, Ukraine

The problem of development of modern biotechnologies for the purposeful use of biocompatible low toxic objects of the nanometer size in the treatment of the most widespread diseases, including diabetes, is analyzed in this review. It is likely that by means of nanotechnologies the problems of early diagnostics of this disease and new effective methods of its selective therapy will be developed.

The modern literature data on the latest biotechnological ways in therapy of diabetes are generalized, in particular the effect in vivo and in vitro of the biocompatible complexes on the basis of carriers of the different nature (glycopolymer, lipid etc.) and multilayered structures with nanoparticles as potential transporters of insulin, and use of biosensors and magnetic probes on the basis of nanoparticles (carbon nanotubes and oxide of iron) for detecting of glucose and visualization of beta-cells of Langergans islands, which produce insulin, are considered under in vivo and in vitro conditions.

Key words: diabetes mellitus, nanomaterials.

© Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, 2008

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Bal R., T
?
rk G., Tuzcu M., Yilmaz O., Ozer-
can I., Kuloglu T., G
?
r S., Nedzvetsky V. S.,
Tykhomyrov A. A., Andrievsky G. V., Bay-
das G., Naziroglu M.
Protective effects of
nanostructures of hydrated C
60
fullerene
on reproductive function in streptozotocin-
diabetic male rats.
Toxicology
. 2011, 282 (3),
69–81.
40.
Wang P., Yoo B., Yang J., Zhang X., Ross A.,
Pantazopoulos P., Dai G., Moore
A.
GLP-
1R–targeting magnetic nanoparticles for
pancreatic islet imaging.
Diabetes.
2014,
63 (5), 1465–1474.
41.
Zhu Zh., Garcia-Gancedo L., Flewitt A. J.,
Xie H., Moussy F., Milne W. I.
A critical
review of glucose biosensors based on carbon
nanomaterials: carbon nanotubes and graphene.
Sensors
, 2012, 12 (5), 5996–6022.
42.
Pyeshkova V. M., Saiapina O. Y., Soldat-
kin O. O., Dzyadevych S. V.
Traditional and
biosensor methods of mono- and disaccharides
determination.
Biotekhnologiia.
2010, 3 (3),
9–22. (In Ukrainian).
43.
Rogaleva N. S., Shkotova L. V., Lvova O. V.,
Garbuz V. V., Muratov V. B., Duda Т. І
.
,
Vasilev O. O., Korpan Ya. І., Biloivan О. А.
Amperometric biosensor modified with
multiwalled carbon nanotubes for glucose
determination.
Biotechnologiіa.
2012, 5 (1),
53–61. (In Ukrainian).
44.
Zhu Z., Song W., Burugapalli K., Moussy F.,
Li Y. L., Zhong X. H.
Nano-yarn carbon nanotube
fiber based enzymatic glucose biosensor.
Nanotechnology.
2010, 21 (16), 165501. doi:
10.1088/0957-4484/21/16/165501.
 

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Home Archive 2015 № 1 NANOMATERIALS IN THE DIAGNOSIS AND THERAPY OF DIABETES MELLITUS M. V. Tolkachev, K. I. Bogutska, O. M. Savchuk, Yu. І. Prylutskyy

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